Real science behind personalized skincare.
Your skin is dynamic.
Skin aging and cosmetic appearance are changeable by interaction with the environment. Your skin is the largest organ of your body. It not only acts as a barrier to protect the body from toxic chemicals, pathogens, and the sun’s ultraviolet radiation, but it also detects changes in the environment such as temperature and pressure. Like all other tissues, skin undergoes degenerative processes during aging from which the healthy appearance can diminish.
Skin is comprised of several layers. The outermost is the visually detectable epidermis consisting of four different types of skin cells. Within the cells is our DNA, a genetic substance. DNA is transcribed into RNA and RNA guides protein synthesis. The proteins are essential for the skin's cellular function and by using these proteins, the cells can regenerate which is crucial for maintaining youthful skin.
Epigenetics, not genetics, determines your skin's dynamics.
Epigenetics is a naturally occurring biological mechanism that primarily refers to the addition of a chemical tag on DNA, a modification which causes genes to be switched either on or off without changes to the underlying DNA sequence. Epigenetics, essentially, affects how genes are read by cells, and subsequently how your genes function.
Each person's epigenetic makeup is unique and can be inherited, but more importantly, evidence shows that epigenetic switches are dynamic and reversible and can be regulated by intervention of medicine, lifestyle and environmental factors. Aging, diet, disease, exercise, and environmental exposure can cause chemical modifications around the genes that will turn those genes on or off over time.
Truly personalized skincare starts with epigenetics.
Your skin's epigenetic states are critical determinants of your skin's health and beauty, which can be reliably identified through our scientifically-backed EpigenCare™ test analysis:
Age dependent epigenetic changes, specifically DNA methylation signatures, have become a hallmark of aging. Skin aging shows dryness, loss of firmness, decrease in elasticity, and an increased risk of wrinkles, acne, and cancer.
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FIRMNESS & ELASTICITY
Collagen and elastin proteins hold your skin together and maintain elasticity. Decrease of these proteins causes fine wrinkles, elasticity loss, reduced thickness, and looseness. The major enzymes or proteins that are responsible for formation, metabolism, secretion, and glycation of collagen and elastin are epigenetically controlled and regulated through DNA methylation or histone modification.
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Moisture is maintained by water transportation proteins and is essential for smooth and bright skin. It also helps with the elasticity of the stratum corneum, preventing tightness and cracking. Activation or repression of water transportation proteins is critically dependent on epigenetic regulation.
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DNA DAMAGE & REPAIR
Environmentally-induced DNA damage is mainly due to excessive exposure to UV radiation in the form of sunlight as well as cigarette smoke and other pollutants. Epigenetic activation of DNA-repair genes or repression of DNA damage reaction pathways become vital for controlling DNA damage/repair mechanisms and cell regeneration.
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Skin cell renewal/regeneration refers to the regrowth of lost skin cells in response to damage or cell death. Weakened ability of cell renewal/regeneration will cause aged skin with wrinkles, age spots, and dryness. The skin also becomes thinner and loses fat, making it appear less full and smooth. Epigenetic changes are proven to be critical determinants for control and regulation of cell renewal and regeneration.
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Sensitive skin and inflammatory response from an immunity reaction to environmental stimuli such as irritants or pollutants can lead to itchiness, redness, peeling, etc., often due to inflammatory protein actions such as cytokines. Regulatory genes or proteins/enzymes for sensitive and inflammatory response pathways are controlled by DNA and histone modification-related gene activation or inactivation.
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OXIDATION & ANTIOXIDATION
Oxidative damage results from an imbalance between free radical generation and antioxidant defenses, which unfavorable symptoms including age spots, wrinkling, and sagging. It is well known that oxidation and antioxidation pathways are controlled by epigenetics, especially by DNA methylation/demethylation of the genes regulating these pathways.
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Coloration of the skin is dependent on the amount of melanin present in the skin, with over-pigmentation from sun exposure or aging leading to skin disease. Skin pigmentation is closely related to epigenetic activation or inactivation of regulatory genes of pigmentation.
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Using the latest technology.
We deploy next-generation sequencing, the gold standard to validate unique epigenetic characteristics.
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Foundation Service + DNA damage/repair and oxidation/antioxidant pathways
Advanced Service + cell regeneration, sensitivity & inflammatory response, and pigmentation